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CCleaner Portable is the portable version of CCleaner, a system optimization and cleaning tool. The desktop version has been downloaded over 375 million times. It makes the system run faster by removing unused items on the computer. It also cleans out the Internet browsing history, cookies and unnecessary temporary files.
With its advanced features, you can also remove unused and old registry entries, including File Extensions, ActiveX Controls, ClassIDs, ProgIDs, Uninstallers etc. It is certainly an essential tool for your USB drive.

The top of the top for AppOnUSB is:
http://www.liberkey.com/fr/component/content/article/17.html
Because: auto-update + Big-Catalogue
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